Biotechnological study of Taraxacum mongolicum function mechanisms

Abstract

Hyperuricemia, as a common metabolic disease, has a rising incidence in recent years, which seriously threatens human health. Dandelion, as a traditional Chinese herbal medicine, has attracted more and more attention for its potential in treating hyperuricemia. Based on network pharmacology and molecular docking technology, this study deeply explored the mechanism of dandelion in treating hyperuricemia. The active components and their targets in Taraxacum mongolicum were screened by network pharmacology, and the potential targets of Taraxacum mongolicum in treating hyperuricemia were determined by combining with the related targets. In this process, we synthesized a variety of database resources, made a comprehensive analysis of the chemical components of Taraxacum mongolicum, and predicted the possible targets of these components through bioinformatics. The drug- ingredient-target-pathway- disease network diagram was constructed, and the interaction between active ingredients of Taraxacum mongolicum and hyperuricemia-related targets was intuitively displayed. On this basis, we further analyzed the interaction network of potential targets, and revealed the key targets involved in the treatment of hyperuricemia by dandelion and their interaction mechanisms. In order to deeply understand the biological process and signal pathway of dandelion in the treatment of hyperuricemia, we carried out GO function enrichment analysis and KEGG signal pathway enrichment analysis. These analyses not only reveal the important role of dandelion active components in regulating the biological processes related to hyperuricemia, but also provide us with the potential mechanism of dandelion in treating hyperuricemia. The interaction between core active components and key targets of Taraxacum mongolicum was verified by molecular docking technology. Through molecular docking simulation, we determined the binding mode of dandelion active components and targets, which further confirmed the effectiveness of dandelion in treating hyperuricemia. The results of this study show that the active components in dandelion participate in the treatment of hyperuricemia by regulating several key targets. These targets involve uric acid metabolism, inflammatory reaction and other aspects, which together constitute the mechanism of dandelion in treating hyperuricemia. This discovery provides a scientific basis for the application of dandelion in the treatment of hyperuricemia, and also provides a new idea for developing new anti-hyperuricemia drugs. This study not only revealed the mechanism of dandelion in treating hyperuricemia, but also verified the application value of network pharmacology and molecular docking technology in Chinese herbal medicine research. Through the comprehensive application of modern pharmacology and bioinformatics, we can dig deeper into the pharmacological mechanism of Chinese herbal medicine and promote the modernization and scientific development of Chinese medicine.